Mitochondrial targeting cancer therapy by naringin in Ehrlich ascites carcinoma-bearing mice

Document Type : Research and Reference

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Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University

10.21608/djs.2025.439350.1238

Abstract

Naringin (NRG), a natural flavanone that has recently gained attention for its pharmacological properties. The present study investigated the mitochondrial-mediated anticancer effects of NRG in EAC-bearing mice. Mice were treated with NRG, and its effects were compared with untreated tumor-bearing controls and cisplatin (Cis)-treated groups. Tumor profile, oxidative stress markers, and mitochondrial functional integrity were assessed. Furthermore, the gene expression analysis was performed using real time PCR to assess apoptotic signaling. The results demonstrated that the treatment with NRG led to significant inhibition of tumor growth, markedly reduced lipid peroxidation, enhanced antioxidant defense systems, and stabilized mitochondrial membrane potential. Additionally, the treatment with NRG triggered the intrinsic apoptotic pathway enhancing tumor cell programmed death. The NRG exerts potent anticancer activity and decreased hepatotoxicity in EAC-bearing mice through mitochondrial targeting mechanisms that induce oxidative stress modulation and intrinsic apoptosis. These findings highlight NRG’s potential as a promising natural compound for mitochondrial-based cancer therapy. NRG could serve as an adjuvant to chemotherapy to reduce toxicity and enhance efficacy.

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Delta Journal of Science
Volume 51, Issue 2
November 2025
Pages 1-14

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