Targeting Skin Carcinogenesis with a New Antitumor therapy: Preclinical Validation hematological and biochemistry studies

Mohammed, Esraa M.; Khamis, Abeer A.; ElHefnawi, Mahmoud; Salim, Elsayed I.

doi:10.21608/djs.2025.397141.1218

Targeting Skin Carcinogenesis with a New Antitumor therapy: Preclinical Validation hematological and biochemistry studies

Document Type : Research and Reference

Authors

¹ Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt, 31527

² Informatics and Systems Department, Engineering Research Division and Centre of Excellence for Advanced Sciences, National Research Centre, Giza, Egypt.

³ Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt, 31527.

10.21608/djs.2025.397141.1218

Abstract

Skin cancer is more common than many other types of cancer and includes a wide variety of benign and malignant neoplasms. Significant morbidity and mortality may be linked to this disorder, which involves the neoplastic proliferation of skin cells and tissues. This study aimed to determine the chemo preventive potential of a novel water-based gel formulation that contained dimethyl arsenic acid (DMA), tocopherol, and ginger oil at both high and low concentrations, either separately or in combination, against chemically induced skin carcinogenesis in a mouse model. Using mouse skin model groundbreaking research identified two basic phases of chemical carcinogenesis: initiation and promotion. The starting agent in these investigations was 7,12-dimethylbenz[a]anthracene (DMBA), whereas the promoting agent was croton oil. DMA in high or low doses, tocopherol, and ginger oil was utilized in a unique gel water formulation as a chemopreventive agent to combat skin cancer. Each medication was given either by itself or in combination. In this investigation, we conducted to show the systemic response to the intervention, antioxidant activity levels, serological, and hematological parameters were analyzed. When compared to untreated cancer-induced controls, the results showed that treatment with the gel formulations led to changes in oxidative stress indicators and hematological parameters. Interestingly, those which received antioxidant-rich combinations showed signals of systemic protection, less oxidative damage. The study presents positive evidence that topical administration of ginger oil, tocopherol, and DMA in a gel formulation may alter immunological responses and systemic oxidative stress, thereby preventing or slowing the growth of skin cancer.

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