The role of Myo-inositol in improving insulin resistance disorder induced in a high fat diet mouse model

Document Type : Research and Reference

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Zoology department, Faculty of Science, Tanta University

Abstract

Recently, the prevalence of insulin resistance (IR) has increased because of lifestyle (availability of fast food, office jobs, and internet). Myo-inositol (MI) was chosen to improve IR as it is present in a variety of foods, essential in several important processes of cell physiology, and synthesized de novo in humans during glycolysis from glucose-6-phosphate (G6P). The effects of MI on certain parameters in a diet-induced obesity mouse model were studied. The study was conducted on 49 male C57BL/6 mice weighing between (23±25 g) of 8 weeks of age and divided into 7 groups (7 mice per each). Group (GP) 1 kept as control with a normal diet and without any treatment, GP 2 received orally 1.2 mg/g of MI, GP 3 received orally 250 mg/kg of Metformin(Met), metformin was used as a reference drug, GP 4 received high-fat diet (HFD) without treatment, GP 5 received HFD with 1.2 mg/g of MI, GP 6 received HFD with 250 mg/kg of Met, GP 7 received HFD with 1.2 mg/g of MI with 250 mg/kg of Met. After 14 weeks of oral administration of MI in a high-fat diet (HFD)--fed C57BL/6 mice. The results showed significant reductions in total body weight, with no effect on lean body weight. Additionally, there was a decrease in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, as well as a decrease in urea and creatinine levels, and an improvement in insulin resistance in obese mice. Meanwhile, reductions in fasting blood glucose, and insulin levels were observed in myo-inositol-treated mice. These results suggest that myo-inositol may be a candidate for the treatment of insulin resistance.

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Delta Journal of Science
Volume 50, Issue 1
February 2025
Pages 147-164

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