Biochemical study on expression of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in Behçet's disease

Document Type : Research and Reference

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1 Chemistry department faculty of science fayoum university

2 Clinical and Chemical pathology Department, Faculty of medicine, Fayoum University, Fayoum

3 Rheumatology and rehabilitation, Faculty of Medicine, Fayoum University, Fayoum

4 Biochemistry departments, Faculty of medicine, Fayoum University, Fayoum

Abstract

Behçet's disease (BD) is a long-term, relapsing, and inflammatory condition that affects various body systems and is characterised by recurring oral and vaginal ulcerations, ocular abnormalities, and other symptoms.

The aim of the study was to assess the expression level metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in BD as an autoimmune disease.

The study comprised 35 BD patients (24 males and 11 females), as well as 30 healthy controls (22 males and 8 females). Blood samples were split into sera, which were then kept at -80 °C until analysis. These sera were employed in the long noncoding extraction and real-time PCR fold change detection of the MALAT1 gene.

Results: There was a significant increase in MALAT1 expression level in cases compared with controls (p = 0.022). ROC curve The MALAT1expression level exhibited an AUC of 0.657 (95% confidence range (CI):0.500-0.814; sensitivity = 65.7, specificity = 100%), which indicated that both Lnc RNAs are useful in distinguishing BD from healthy controls.

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