SERUM LIPIDS, LIPOPROTEINS AND URIC ACID IN TYPE II DIABETES MELLITUS ON SULPHONYLUREA AND INSULIN MEDICATIONS

Bugrin, Salah N.; Gargum, I.; Alberghothy, Abd-Alhamed K.

doi:10.21608/djs.2005.156246

SERUM LIPIDS, LIPOPROTEINS AND URIC ACID IN TYPE II DIABETES MELLITUS ON SULPHONYLUREA AND INSULIN MEDICATIONS

Document Type : Research and Reference

Authors

Chem. Dept., Fac. Of Science, Garyounis Univ., Benghazi-Libya

10.21608/djs.2005.156246

Abstract

One hundred and forty five, non-insulin dependent-diabetes Mellitus (NIDDM), without ischemic heart disease, one hundred and twenty three, NIDDM, with ischemic heart disease patients and eighty-seven healthy subjects were selected in this study. NIDDM patients (group III) showed highly significant increase of total LDL, VLDL cholesterol, triglycerides and uric acid with low levels of HDL-c compared to NIDDM (group II) and healthy subjects (group I).except for uric acid and HDL-c, all parameters of NIDDM group showed high concentrations compared to healthy subjects. The NIDDM group ischemic heart disease showed a significantly increase for triglycerides (TG and VLDL-c but no significant increase was noticed for uric acid (UA) on oral medication of hypoglycemic agent (sulphonylurea) compared to the medication of insulin.
The NIDDM patients with ischemic heart disease showed a higher results for total cholesterol (TC), LDL-c, VLDL-c, TG and a lower result for HDL-c upon medication of oral hypoglycemic agent (sulphonylurea) compared to the medication of insulin.