Effect of Some New Aza – Uracil Derivatives in Treatment of Schistosoma mansoni Infection

Salama, Afrah F.; El-Barbary, Ahmed A.; Al-Sharkawi, Ismail M.; Helal, Yara A.

doi:10.21608/djs.2013.139770

Effect of Some New Aza – Uracil Derivatives in Treatment of Schistosoma mansoni Infection

Document Type : Research and Reference

Authors

¹ Chemistry Department, Biochemistry, Department, Faculty of Science- Tanta University, Egypt.

² Chemistry Department, Organic Chemistry Section,Department, Faculty of Science- Tanta University, Egypt.

³ Chemistry Department, Biochemistry, Department, Faculty of Science- Tanta University, Egypt

10.21608/djs.2013.139770

Abstract

Praziquantel is now the drug of choice for treatment of schistosomiasis, its use in the control of
schistosomiasis at a population level faces some problems, and thus a search for new drugs with
antischistosomal activity is urgently needed. In the present study we worked on newly
synthesized 1, 2, 4-triazine derivative compounds. The study was carried out on 190 female
mice for the assessment of the antischistosomal activity of 1,2,4-triazine compounds, with
special reference to histopathological examination and some liver tissues biochemical
parameters. The results showed four compounds 3, 6, 7 and 10 caused suppressive effect on the
development of granuloma reaction as compared with Schistosoma infected only. Compound 10
had the highest effect in reducing worm burden lesser sever enzymatic dysfunction. Some
compounds caused a marked improvement in almost enzymatic activity particularly 5`-
nucleotidase, G6P, Na-K ATPase and Mg-ATPase activities. ALT and AST activities decreased
than the normal. Also, some compounds showed improvement in catalase and GST enzyme
activities indicating their antioxidant effect .Some compounds as 9 and 10 showed antischistosomal
activity; also compounds 3, 6 and 10 had anti-inflammatory activity.

Keywords