Age-related biochemical and histological changes in the soleus muscle of male mice

Document Type : Research and Reference

Authors

1 Zoology Department, Faculty of Science, Kafrelsheikh University, Egypt

2 Zoology Department, Faculty of Science, Tanta University, Egypt

Abstract

During aging, skeletal muscle is subjected to progressive
loss of muscle mass and strength (sarcopenia) and a decline in the
functional ability. The reduction in the antioxidative capacity of
the skeletal muscle resulting in an abnormal accumulation of the
reactive oxygen species (ROS) that is one of the possible causes
of the decline in muscle performance. In this study the
histological changes in the soleus muscles of male mice at the age
of 1st and 15th old were examined and the activities of the
antioxidant enzymes, CAT and SOD, non- enzymatic antioxidant
GPH and MDA level were measured to clarify the age-related
changes in healthy subjects. Results showed that there is a
significant reduction (P ≤ 0.05) in the antioxidants SOD, CAT
and GPH and there is a significant increase (P ≤ 0.05) in MDA
level at the age of 15th month when compared to 1st month old.
We concluded that the activities of the antioxidants were affected
by aging. Moreover, there is age- related lipid peroxidation.

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