Synthesis and Antibacterial Activity of Schiff base Compounds Based on Poloxamine

Document Type : Research and Reference

Authors

1 Department of Chemistry, Faculty of Science, Tanta University, Tanta

2 Department of Chemistry, Faculty of Science, Tanta University

3 Polymer Research Group, Department of Chemistry, Faculty of Science, Tanta University

Abstract

The hydroxyl end groups of Tetronic T1107 were modified with chloroacetyl
chloride. The chloroacetylated Tetronic T1107 was then modified to
introduce amino group in the side chain by reacting it with ethylenediamine.
New Schiff bases were synthesized by the reaction of aminated Tetronic
1107 with different aromatic aldehydes such as p-hydroxybenzaldehyde,
vanillin, p-chlorobenzaldehyde, and p-dimethylamino benzaldehyde. The
chemical structure of the obtained Schiff bases was confirmed by FT-IR and
1H-NMR spectroscopy. The antibacterial activity of Schiff base compounds
was investigated by well diffusion method against gram-negative bacteria
(Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris) and grampositive
bacteria (Staphylococcus aureus). The results showed that the
polymeric Schiff base compounds have a significant inhibiting effect on all
the tested microorganisms. It was also found that the antibacterial activity of
the Schiff base was higher than that of unmodified tetronic 1107.

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